國立中興大學科研產業化平台

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  • 專利名稱(中文) / 開發具有改善腸胃道功能之黑蒜萃取物
  • 專利名稱(英文) / Developing Black Garlic Extract with Improved Gastrointestinal Function
  • 所屬單位(一級單位) / 農業暨自然資源學院
  • 所屬單位(二級單位) / 食品暨應用生物科技學系
  • 發明人(中文) / 謝昌衛
  • 發明人(英文) / Chang-Wei Hsieh
  • 申請國家 /
  • 專利類型 /
  • 專利證書號 / I600431
  • 技術成熟度 /

大蒜已被文獻指出具有促進排便的功能,然而,目前僅有少數研究針對黑蒜改善腸胃道的功能進行探討。5-HT4為位於腸胃道肌間神經叢具有高度親和力的受體,能夠促進腸道的膽鹼能神經元釋放乙醯膽鹼,使平滑肌收縮,進而促進腸道蠕動。本技術透過分層萃取,探討黑蒜萃取液中不同萃取層對於腸胃道功能的影響。結果顯示,黑蒜的正丁醇萃取層可以透過增加5-HT4的含量來直接影響腸道蠕動,有效地促進腸胃道排空及排便功能。實驗結果也證實黑蒜多醣在促進腸胃道健康效果方面具有很大的潛力,未來可望將黑蒜多醣應用於具有改善腸胃道功能的藥品,甚至開發成新型態的黑蒜保健產品。

Garlic has been pointed out that it can promote defecation. However, only a few studies have focused on improving the function of gastrointestinal tract in black garlic. 5-HT4 is a receptor with high affinity in the gastrointestinal tract myenteric plexus, which can promote the release of acetylcholine from cholinergic neurons in the intestine, shrinking smooth muscle, and promoting intestinal peristalsis. The technology explores the effects of different extract layers on the function of gastrointestinal tract in black garlic extract through layered extraction. The results showed that the n-butanol extract layer of black garlic can directly affect the intestinal peristalsis by increasing the content of 5-HT4, and effectively promote the gastrointestinal emptying and defecation function. The experimental results also confirmed that black garlic polysaccharide has great potential in promoting the health effect of gastrointestinal tract. In the future, black garlic polysaccharide can be applied to medicines with improved gastrointestinal function, and even developed into a new type of black garlic health care product.

黑蒜、腸胃道功能、5-羥色胺4受體、多醣

Black Garlic; Gastrointestinal Tract Function; 5-HT4; Polysaccharide


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